AI could optimize the treatment of prostate cancer
According to a presentation at the American Society of Clinical Oncology (ASCO) meeting on June 4, an artificial intelligence (AI)-driven biomarker has been developed to identify men with high-risk, localized prostate cancer who can be spared long-term hormone therapy.
The research was conducted by the Duke Cancer Institute in collaboration with ArteraAI.
Long-term hormone therapy, also called androgen deprivation therapy (ADT), is often used in addition to radiation in the treatment of high-risk, localized prostate cancer.
However, not all men need this treatment long-term, which is associated with possible side effects.
Successful AI-based digital pathology tool
The AI-based biomarker was trained using data from six clinical trials involving over 2,600 men with prostate cancer treated with long-term ADT and radiation.
This AI tool digitally analyzed patients’ biopsies and clinical data to determine which men could avoid long-term ADT without increasing the risk of developing cancer.
After the training phase, the AI-based tool was validated in a randomized, controlled study on a further 1,192 patients.
Results of the study
The results of the study were promising: the predictive AI biomarker identified 34% of men who could benefit from short-term ADT.
These men could avoid the side effects of prolonged ADT without compromising the effectiveness of the treatment.
Additionally, the biomarker identified 43% of intermediate-risk men who would benefit from long-term ADT to reduce their risk of metastasis over time.
Quote from the lead researcher
“Together with radiation therapy, ADT improves survival and reduces the risk of metastasis in men with high-risk, localized prostate cancer, but not all men need to receive therapy long-term,” said lead author Andrew J. Armstrong, MD, professor in the departments of medicine, surgery and pharmacology and Cancer Biology at Duke University School of Medicine.
“A predictive biomarker that accurately identifies men with localized, high-risk prostate cancer and provides them with more optimal and personalized care would save many people from unnecessary treatments while identifying those men who would benefit most.”
If you are interested in prostate cancer, please read the relevant studies Coffee may help reduce the risk of prostate cancerAnd Dairy products can increase the risk of prostate cancer in men.
For more information on cancer, see recent studies that a A low-carb diet could increase the overall risk of cancerand results are displayed Vitamin D supplements significantly reduce cancer death rates.
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