Combination of surgery and drug for obesity

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The treatment

A new treatment that combines a procedure-free swallowable gastric balloon and the commonly prescribed anti-obesity drug, liraglutide, is a safe and effective way to lose weight, according to an international, multi-center study presented at the European Congress on Obesity (ECO) in Dublin increase.

The Allurion balloon, also known as the Elipse, is the world’s first and only non-invasive swallowable gastric balloon.

It is inserted without surgery, endoscopy or anesthesia and leaves the body naturally after about 16 weeks.

Liraglutide, sold under the brand name Saxenda, is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) that increases feelings of fullness (satiation), suppresses appetite, and is used in the treatment of obesity and type 2 – Diabetes is effective.

The study

The one from Dr. Roberta Ienca at the Nuova Villa Claudia Clinic in Rome evaluated the efficacy and safety of the Allurion balloon in combination with liraglutide.

A total of 181 patients (145 women and 36 men) were enrolled in three international multidisciplinary obesity centers in Italy, Spain and Egypt.

After swallowing, the balloon in the stomach fills with fluid. Placement is a 20-minute outpatient visit and the balloon typically remains in the patient for 15 to 17 weeks.

Between 4 and 16 weeks after balloon placement, liraglutide was added once daily to promote weight loss and increase patient satisfaction.

After 16 weeks of balloon treatment, participants lost an average of 13 kg and 14% of their original body weight, well above the 5-10% considered clinically meaningful weight loss.

After the balloon left the body, the patients switched to a Mediterranean diet to maintain weight and used liraglutide for at least six months.

At the end of treatment with liraglutide, the participants lost an average of 18 kg and 19% of their original body weight.

safety and effectiveness

No serious adverse events were registered. Balloon-related adverse events such as nausea, vomiting, and abdominal cramps have been managed with medication.

Adverse events associated with liraglutide included nausea, diarrhea, constipation, and headache.

dr Ienca explained that the Allurion program provides excellent non-surgical weight loss for people who are overweight and obese, and that liraglutide can safely further increase weight loss.

She added, “The ease of use, low rate of adverse events, and potentially lower cost of the Allurion program could allow for the far broader application of this important intervention, ultimately benefiting the millions of people struggling with obesity and its associated health complications.” .” ”

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