Scientists Develop Revolutionary New Treatment for Polycystic Ovarian Syndrome (PCOS)

Image credit: Unsplash+.

Researchers at the University of Chicago have developed a potentially transformative treatment for polycystic ovary syndrome (PCOS), a common endocrine disorder that affects millions of women worldwide.

This novel treatment aims to go beyond just symptom management and address the underlying causes of PCOS.

The Science: Mesenchymal Stem Cells and Exosomes

The research focuses on mesenchymal stem cell-derived extracellular vesicles (MSC-derived EVs), also called exosomes.

These are small packages of molecules that release stem cells, and they appear to play a crucial role in relieving PCOS symptoms.

“Our approach represents a paradigm shift from managing symptoms to treating underlying causes,” said Hang-Soo Park, Ph.D., the study’s lead author.

“We hope this will prove more effective in the long term and allow patients to have children if they wish.”

How it works

Through experiments, researchers discovered that these MSC-derived EVs can downregulate genes responsible for the overproduction of androgen hormones, a hallmark of PCOS.

When injected into mouse models, the EVs not only stabilized metabolic irregularities such as elevated glucose levels, but also restored ovarian function.

Anti-inflammatory mechanisms

The researchers suspect that an immune signaling protein, IL-10, known for its anti-inflammatory properties, may be central to the observed therapeutic effects.

The exosomes act as a transport system by transporting IL-10 to target cells and enhancing its anti-inflammatory and restorative effects.

Advantages over current treatments

Conventional treatments for PCOS often involve the use of oral contraceptives, which do not address the fertility problems often associated with the condition. This new treatment method offers significant advantages over existing options, including:

More accessibility: In contrast to whole stem cell therapy, the use of EVs is potentially more cost-effective.

Better safety profile: Minimal concerns for tumor formation or immunogenic reactions.

Preservation of fertility: The aim of treatment is to restore ovarian function, a crucial factor for women who want to become pregnant.

Towards human clinical trials

Clinical trials of EV therapy for reproductive disorders have already been approved, increasing the likelihood that this research will be translated into practical applications.

The team is now seeking grants to fund human clinical trials and is working to improve the EVs’ precision in targeting ovarian tissue.


This groundbreaking study was published in the International Journal of Molecular Sciences and offers new hope for treating the root causes of PCOS. While there is still much work to be done, the potential to revolutionize PCOS treatment is enormous.

“The more we understand, the safer and more effective treatments will become,” Park concluded.

For countless women grappling with the complexities of PCOS, this research could herald the beginning of a new era of treatment and fertility options.

If you care about breast cancer, please read studies about cardiac risks in breast cancer treatment and the results of breast cancer screenings that benefit women in their 40s.

If you would like to learn more about breast cancer, please read Studies about one of the leading causes of fatal breast cancer and about common blood pressure medications that may increase the risk of death from breast cancer.

The research results can be found in the International Journal of Molecular Sciences.

follow us on Twitter for more articles on this topic.

Copyright © 2023 Knowridge Science Report. All rights reserved.

Laura Coffey

Laura Coffey is a Worldtimetodays U.S. News Reporter based in Canada. His focus is on U.S. politics and the environment. He has covered climate change extensively, as well as healthcare and crime. Laura Coffey joined Worldtimetodays in 2023 from the Daily Express and previously worked for Chemist and Druggist and the Jewish Chronicle. He is a graduate of Cambridge University. Languages: English. You can get in touch with me by emailing:

Related Articles

Back to top button